EOD31015

Description : DNA topoisomerase type I [Ensembl].

Gene families : OG_01_0002413 (OrthoFinder) Phylogenetic Tree(s): OG0002413_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: EOD31015
Cluster	HCCA: Cluster_237

Target	Alias	Description	ECC score	Gene Family Method
Cre03.g178600	30787789, TOP1	Cell cycle.interphase.DNA replication.preinitiation.TOP1...	0.04	OrthoFinder
Dusal.0007s00039.1	33201185	DNA topoisomerase I, catalytic core, eukaryotic-type;...	0.03	OrthoFinder
PTI_11G01100.1	No alias	DNA topoisomerase I, DNA binding, eukaryotic-type;...	0.03	OrthoFinder
Sro1053_g235820.1	Contig4118.g31453	DNA topoisomerase 1	0.02	OrthoFinder
lcl\|BLLF01002372.1_cds_GFH23824.1_18301	HaLaN_21508, GFH23824	DNA topoisomerase 1	0.04	OrthoFinder
lcl\|LHPG02000023.1_cds_PRW20584.1_5407	PRW20584	DNA topoisomerase 1-like	0.04	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000151	ubiquitin ligase complex	IEP	Enrichment
MF	GO:0000155	phosphorelay sensor kinase activity	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Enrichment
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Enrichment
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Enrichment
MF	GO:0003682	chromatin binding	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003774	motor activity	IEP	Enrichment
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Enrichment
MF	GO:0004402	histone acetyltransferase activity	IEP	Enrichment
MF	GO:0004518	nuclease activity	IEP	Enrichment
MF	GO:0004673	protein histidine kinase activity	IEP	Enrichment
MF	GO:0004827	proline-tRNA ligase activity	IEP	Enrichment
MF	GO:0005049	nuclear export signal receptor activity	IEP	Enrichment
MF	GO:0005198	structural molecule activity	IEP	Enrichment
MF	GO:0005515	protein binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
MF	GO:0005525	GTP binding	IEP	Enrichment
CC	GO:0005575	cellular_component	IEP	Enrichment
CC	GO:0005634	nucleus	IEP	Enrichment
CC	GO:0005667	transcription regulator complex	IEP	Enrichment
CC	GO:0005694	chromosome	IEP	Enrichment
BP	GO:0006302	double-strand break repair	IEP	Enrichment
BP	GO:0006325	chromatin organization	IEP	Enrichment
BP	GO:0006338	chromatin remodeling	IEP	Enrichment
BP	GO:0006351	transcription, DNA-templated	IEP	Enrichment
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Enrichment
BP	GO:0006396	RNA processing	IEP	Enrichment
BP	GO:0006397	mRNA processing	IEP	Enrichment
BP	GO:0006433	prolyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006473	protein acetylation	IEP	Enrichment
BP	GO:0006475	internal protein amino acid acetylation	IEP	Enrichment
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEP	Enrichment
BP	GO:0006886	intracellular protein transport	IEP	Enrichment
BP	GO:0008104	protein localization	IEP	Enrichment
BP	GO:0008380	RNA splicing	IEP	Enrichment
BP	GO:0009056	catabolic process	IEP	Enrichment
BP	GO:0009057	macromolecule catabolic process	IEP	Enrichment
BP	GO:0009058	biosynthetic process	IEP	Enrichment
BP	GO:0009059	macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0009889	regulation of biosynthetic process	IEP	Enrichment
BP	GO:0010468	regulation of gene expression	IEP	Enrichment
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0015031	protein transport	IEP	Enrichment
BP	GO:0016070	RNA metabolic process	IEP	Enrichment
BP	GO:0016192	vesicle-mediated transport	IEP	Enrichment
CC	GO:0016459	myosin complex	IEP	Enrichment
MF	GO:0016462	pyrophosphatase activity	IEP	Enrichment
BP	GO:0016569	covalent chromatin modification	IEP	Enrichment
BP	GO:0016570	histone modification	IEP	Enrichment
BP	GO:0016573	histone acetylation	IEP	Enrichment
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Enrichment
MF	GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	IEP	Enrichment
MF	GO:0016779	nucleotidyltransferase activity	IEP	Enrichment
MF	GO:0016787	hydrolase activity	IEP	Enrichment
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Enrichment
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Enrichment
MF	GO:0017069	snRNA binding	IEP	Enrichment
MF	GO:0017070	U6 snRNA binding	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Enrichment
BP	GO:0018130	heterocycle biosynthetic process	IEP	Enrichment
BP	GO:0018205	peptidyl-lysine modification	IEP	Enrichment
BP	GO:0018393	internal peptidyl-lysine acetylation	IEP	Enrichment
BP	GO:0018394	peptidyl-lysine acetylation	IEP	Enrichment
MF	GO:0019001	guanyl nucleotide binding	IEP	Enrichment
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Enrichment
BP	GO:0019222	regulation of metabolic process	IEP	Enrichment
MF	GO:0019239	deaminase activity	IEP	Enrichment
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Enrichment
MF	GO:0019899	enzyme binding	IEP	Enrichment
BP	GO:0019941	modification-dependent protein catabolic process	IEP	Enrichment
CC	GO:0030117	membrane coat	IEP	Enrichment
CC	GO:0030120	vesicle coat	IEP	Enrichment
CC	GO:0030126	COPI vesicle coat	IEP	Enrichment
MF	GO:0030145	manganese ion binding	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
MF	GO:0030623	U5 snRNA binding	IEP	Enrichment
BP	GO:0031323	regulation of cellular metabolic process	IEP	Enrichment
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Enrichment
MF	GO:0031491	nucleosome binding	IEP	Enrichment
MF	GO:0031625	ubiquitin protein ligase binding	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Enrichment
BP	GO:0032774	RNA biosynthetic process	IEP	Enrichment
CC	GO:0032991	protein-containing complex	IEP	Enrichment
BP	GO:0033036	macromolecule localization	IEP	Enrichment
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Enrichment
MF	GO:0034212	peptide N-acetyltransferase activity	IEP	Enrichment
MF	GO:0034450	ubiquitin-ubiquitin ligase activity	IEP	Enrichment
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
BP	GO:0043044	ATP-dependent chromatin remodeling	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
CC	GO:0043226	organelle	IEP	Enrichment
CC	GO:0043227	membrane-bounded organelle	IEP	Enrichment
CC	GO:0043229	intracellular organelle	IEP	Enrichment
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Enrichment
BP	GO:0043543	protein acylation	IEP	Enrichment
BP	GO:0043632	modification-dependent macromolecule catabolic process	IEP	Enrichment
BP	GO:0044248	cellular catabolic process	IEP	Enrichment
BP	GO:0044249	cellular biosynthetic process	IEP	Enrichment
BP	GO:0044265	cellular macromolecule catabolic process	IEP	Enrichment
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Enrichment
MF	GO:0044389	ubiquitin-like protein ligase binding	IEP	Enrichment
MF	GO:0044877	protein-containing complex binding	IEP	Enrichment
BP	GO:0045184	establishment of protein localization	IEP	Enrichment
BP	GO:0046907	intracellular transport	IEP	Enrichment
MF	GO:0046983	protein dimerization activity	IEP	Enrichment
BP	GO:0050789	regulation of biological process	IEP	Enrichment
BP	GO:0050794	regulation of cellular process	IEP	Enrichment
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Enrichment
BP	GO:0051252	regulation of RNA metabolic process	IEP	Enrichment
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	IEP	Enrichment
BP	GO:0051641	cellular localization	IEP	Enrichment
BP	GO:0051649	establishment of localization in cell	IEP	Enrichment
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Enrichment
MF	GO:0061630	ubiquitin protein ligase activity	IEP	Enrichment
MF	GO:0061659	ubiquitin-like protein ligase activity	IEP	Enrichment
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	IEP	Enrichment
BP	GO:0065007	biological regulation	IEP	Enrichment
BP	GO:0071702	organic substance transport	IEP	Enrichment
BP	GO:0071705	nitrogen compound transport	IEP	Enrichment
BP	GO:0080090	regulation of primary metabolic process	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
BP	GO:0097659	nucleic acid-templated transcription	IEP	Enrichment
MF	GO:0097747	RNA polymerase activity	IEP	Enrichment
CC	GO:0098796	membrane protein complex	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140104	molecular carrier activity	IEP	Enrichment
MF	GO:0140142	nucleocytoplasmic carrier activity	IEP	Enrichment
MF	GO:0140299	small molecule sensor activity	IEP	Enrichment
MF	GO:0140597	protein carrier activity	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Enrichment
BP	GO:1901575	organic substance catabolic process	IEP	Enrichment
BP	GO:1901576	organic substance biosynthetic process	IEP	Enrichment
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Enrichment
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Enrichment
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR013500	TopoI_cat_euk	415	665
IPR025834	TopoI_C_dom	700	768
IPR008336	TopoI_DNA-bd_euk	193	411

External Links

No external refs found!

EOD31015

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation