EOD13547

Description : Dihydrofolate reductase domain; Thymidylate synthase/dCMP hydroxymethylase domain [Interproscan].

Gene families : OG_01_0002862 (OrthoFinder) Phylogenetic Tree(s): OG0002862_tree

Sequence : coding (download), protein (download)

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: EOD13547
Cluster	HCCA: Cluster_201

Target	Alias	Description	ECC score	Gene Family Method
Cre17.g715900	30781940	Coenzyme metabolism.tetrahydrofolate...	0.12	OrthoFinder
Cz03g17210.t1	No alias	Dihydrofolate reductase domain; Thymidylate...	0.01	OrthoFinder
Dusal.0422s00002.1	33186848	Thymidylate synthase/dCMP hydroxymethylase domain [Interproscan].	0.03	OrthoFinder
OT_01G05960.1	No alias	Dihydrofolate reductase domain; Thymidylate...	0.09	OrthoFinder
PTI_14G00450.1	No alias	Thymidylate synthase/dCMP hydroxymethylase domain [Interproscan].	0.02	OrthoFinder
Sro174_g076600.1	Contig4298.g32444	Thymidylate synthase	0.05	OrthoFinder
Vocar.0005s0400.1	32883691	Thymidylate synthase/dCMP hydroxymethylase domain;...	0.02	OrthoFinder
XM_002502500.1	MICPUN_58650, 58650	Bifunctional dihydrofolate reductase-thymidylate...	0.12	OrthoFinder
XM_003056851.1	MicpuC2_56456, 56456	Bifunctional dihydrofolate reductase-thymidylate...	0.06	OrthoFinder
lcl\|BLLF01003473.1_cds_GFH27435.1_21912	HaLaN_25755, GFH27435	Bifunctional dihydrofolate reductase-thymidylate synthase	0.05	OrthoFinder
lcl\|LHPG02000012.1_cds_PRW44987.1_1730	PRW44987	Bifunctional dihydrofolate reductase-thymidylate synthase	0.04	OrthoFinder
lcl\|VRMN01000001.1_cds_KAA8499242.1_8195	KAA8499242	Bifunctional dihydrofolate reductase-thymidylate synthase 1	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004146	dihydrofolate reductase activity	IEA	Interproscan
BP	GO:0006575	cellular modified amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006760	folic acid-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009396	folic acid-containing compound biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0042398	cellular modified amino acid biosynthetic process	None	Extended
BP	GO:0042558	pteridine-containing compound metabolic process	None	Extended
BP	GO:0042559	pteridine-containing compound biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046653	tetrahydrofolate metabolic process	None	Extended
BP	GO:0046654	tetrahydrofolate biosynthetic process	IEA	Interproscan
BP	GO:0055114	obsolete oxidation-reduction process	IEA	Interproscan
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
BP	GO:0001932	regulation of protein phosphorylation	IEP	Enrichment
MF	GO:0003676	nucleic acid binding	IEP	Enrichment
MF	GO:0003677	DNA binding	IEP	Enrichment
MF	GO:0003682	chromatin binding	IEP	Enrichment
MF	GO:0003689	DNA clamp loader activity	IEP	Enrichment
MF	GO:0003690	double-stranded DNA binding	IEP	Enrichment
MF	GO:0003852	2-isopropylmalate synthase activity	IEP	Enrichment
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Enrichment
MF	GO:0003896	DNA primase activity	IEP	Enrichment
MF	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	IEP	Enrichment
MF	GO:0003909	DNA ligase activity	IEP	Enrichment
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Enrichment
MF	GO:0004345	glucose-6-phosphate dehydrogenase activity	IEP	Enrichment
MF	GO:0004601	peroxidase activity	IEP	Enrichment
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
CC	GO:0005634	nucleus	IEP	Enrichment
CC	GO:0005663	DNA replication factor C complex	IEP	Enrichment
CC	GO:0005694	chromosome	IEP	Enrichment
BP	GO:0006006	glucose metabolic process	IEP	Enrichment
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Enrichment
BP	GO:0006259	DNA metabolic process	IEP	Enrichment
BP	GO:0006260	DNA replication	IEP	Enrichment
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Enrichment
BP	GO:0006270	DNA replication initiation	IEP	Enrichment
BP	GO:0006275	regulation of DNA replication	IEP	Enrichment
BP	GO:0006281	DNA repair	IEP	Enrichment
BP	GO:0006298	mismatch repair	IEP	Enrichment
BP	GO:0006304	DNA modification	IEP	Enrichment
BP	GO:0006305	DNA alkylation	IEP	Enrichment
BP	GO:0006306	DNA methylation	IEP	Enrichment
BP	GO:0006310	DNA recombination	IEP	Enrichment
BP	GO:0006551	leucine metabolic process	IEP	Enrichment
BP	GO:0006950	response to stress	IEP	Enrichment
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Enrichment
BP	GO:0006979	response to oxidative stress	IEP	Enrichment
BP	GO:0008156	negative regulation of DNA replication	IEP	Enrichment
MF	GO:0008170	N-methyltransferase activity	IEP	Enrichment
BP	GO:0009059	macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0009098	leucine biosynthetic process	IEP	Enrichment
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Enrichment
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Enrichment
BP	GO:0009889	regulation of biosynthetic process	IEP	Enrichment
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Enrichment
BP	GO:0009892	negative regulation of metabolic process	IEP	Enrichment
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Enrichment
BP	GO:0016070	RNA metabolic process	IEP	Enrichment
MF	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IEP	Enrichment
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Enrichment
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Enrichment
MF	GO:0016779	nucleotidyltransferase activity	IEP	Enrichment
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
CC	GO:0018995	host cellular component	IEP	Enrichment
BP	GO:0019220	regulation of phosphate metabolic process	IEP	Enrichment
BP	GO:0019222	regulation of metabolic process	IEP	Enrichment
MF	GO:0019899	enzyme binding	IEP	Enrichment
MF	GO:0019900	kinase binding	IEP	Enrichment
MF	GO:0019901	protein kinase binding	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
MF	GO:0030983	mismatched DNA binding	IEP	Enrichment
BP	GO:0031323	regulation of cellular metabolic process	IEP	Enrichment
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Enrichment
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Enrichment
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Enrichment
BP	GO:0031399	regulation of protein modification process	IEP	Enrichment
BP	GO:0032268	regulation of cellular protein metabolic process	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
BP	GO:0032774	RNA biosynthetic process	IEP	Enrichment
BP	GO:0033554	cellular response to stress	IEP	Enrichment
CC	GO:0033643	host cell part	IEP	Enrichment
CC	GO:0033646	host intracellular part	IEP	Enrichment
CC	GO:0033647	host intracellular organelle	IEP	Enrichment
CC	GO:0033648	host intracellular membrane-bounded organelle	IEP	Enrichment
MF	GO:0034061	DNA polymerase activity	IEP	Enrichment
MF	GO:0034062	5'-3' RNA polymerase activity	IEP	Enrichment
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Enrichment
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
CC	GO:0042025	host cell nucleus	IEP	Enrichment
BP	GO:0042325	regulation of phosphorylation	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0043170	macromolecule metabolic process	IEP	Enrichment
CC	GO:0043226	organelle	IEP	Enrichment
CC	GO:0043227	membrane-bounded organelle	IEP	Enrichment
CC	GO:0043229	intracellular organelle	IEP	Enrichment
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Enrichment
BP	GO:0043414	macromolecule methylation	IEP	Enrichment
BP	GO:0043549	regulation of kinase activity	IEP	Enrichment
BP	GO:0044238	primary metabolic process	IEP	Enrichment
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Enrichment
BP	GO:0044728	DNA methylation or demethylation	IEP	Enrichment
BP	GO:0045005	DNA-dependent DNA replication maintenance of fidelity	IEP	Enrichment
BP	GO:0045859	regulation of protein kinase activity	IEP	Enrichment
MF	GO:0046912	acyltransferase, acyl groups converted into alkyl on transfer	IEP	Enrichment
BP	GO:0048478	replication fork protection	IEP	Enrichment
BP	GO:0048519	negative regulation of biological process	IEP	Enrichment
BP	GO:0048523	negative regulation of cellular process	IEP	Enrichment
BP	GO:0050789	regulation of biological process	IEP	Enrichment
BP	GO:0050790	regulation of catalytic activity	IEP	Enrichment
BP	GO:0050794	regulation of cellular process	IEP	Enrichment
BP	GO:0050896	response to stimulus	IEP	Enrichment
BP	GO:0051174	regulation of phosphorus metabolic process	IEP	Enrichment
BP	GO:0051246	regulation of protein metabolic process	IEP	Enrichment
BP	GO:0051338	regulation of transferase activity	IEP	Enrichment
BP	GO:0051716	cellular response to stimulus	IEP	Enrichment
BP	GO:0051726	regulation of cell cycle	IEP	Enrichment
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Enrichment
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Enrichment
BP	GO:0065007	biological regulation	IEP	Enrichment
BP	GO:0065009	regulation of molecular function	IEP	Enrichment
BP	GO:0071900	regulation of protein serine/threonine kinase activity	IEP	Enrichment
BP	GO:0090304	nucleic acid metabolic process	IEP	Enrichment
BP	GO:0090329	regulation of DNA-dependent DNA replication	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
MF	GO:0097747	RNA polymerase activity	IEP	Enrichment
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment
BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	IEP	Enrichment
BP	GO:2000104	negative regulation of DNA-dependent DNA replication	IEP	Enrichment
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Enrichment
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR023451	Thymidate_synth/dCMP_Mease_dom	244	495
IPR001796	DHFR_dom	17	156

External Links

No external refs found!

EOD13547

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation