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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


There are 6545 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_1 Chlamydomonas reinhardtii 1.74 % 0.000201 0.002752
Cluster_126 Chlorella vulgaris 2.41 % 0.000934 0.006274
Cluster_43 Chlorella vulgaris 2.7 % 0.000744 0.0023
Cluster_216 Chlorella vulgaris 3.85 % 0.000368 0.003703
Cluster_206 Chromochloris zofingiensis 100.0 % 6e-06 4.5e-05
Cluster_156 Chromochloris zofingiensis 5.88 % 0.000247 0.037053
Cluster_100 Cladocopium sp. clade C 3.07 % 5.2e-05 0.000448
Cluster_840 Cladocopium sp. clade C 50.0 % 0.004895 0.039159
Cluster_171 Dunaliella sp. 50.0 % 0.002394 0.018356
Cluster_76 Dunaliella sp. 2.15 % 0.005463 0.04065
Cluster_114 Dunaliella sp. 3.85 % 0.001744 0.015694
Cluster_680 Emiliania huxleyi 100.0 % 1e-06 1.2e-05
Cluster_194 Emiliania huxleyi 2.5 % 0.003801 0.034755
Cluster_758 Emiliania huxleyi 50.0 % 0.002281 0.019391
Cluster_139 Emiliania huxleyi 1.85 % 0.000109 0.019695
Cluster_189 Haematococcus lacustris 2.38 % 0.001293 0.007003
Cluster_19 Ostreococcus tauri 3.23 % 0.001038 0.034858
Cluster_6 Ostreococcus tauri 1.76 % 0.005791 0.025771
Cluster_67 Porphyridium purpureum 3.66 % 0.000343 0.035472
Cluster_8 Seminavis robusta 2.54 % 0.000336 0.002219
Cluster_35 Seminavis robusta 2.07 % 8e-06 0.000247
Cluster_214 Seminavis robusta 2.9 % 0.002837 0.016128
Cluster_9 Seminavis robusta 1.2 % 0.015448 0.04244
Sequences (6545) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !